Differences in Cost-Effectiveness Estimates for Chronic Hepatitis C Treatment Among Cohort Markov Model, Markov Microsimulation and Discrete Event Simulation
نویسندگان
چکیده
منابع مشابه
Cohort decomposition for Markov cost-effectiveness models.
Cohort analysis is a widespread tool for computing expected costs and quality-adjusted life years (QALYs) in Markov models for medical cost-effectiveness analyses. Although not always explicitly identified, such models commonly have multiple simple factors, or components. In these, a health state consists of a multiple component vector, one component for each factor, and arbitrary combinations ...
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The choice of model design for decision analytic models in cost-effectiveness analysis has been the subject of discussion. The current work addresses this issue by noting that, when time is to be explicitly modelled, we need to represent phenomena occurring in continuous time. Multistate models evaluated in continuous time might be used but closed form solutions of expected time in each state m...
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Abstract. We propose a Markov model for the spread of Hepatitis C virus (HCV) among drug users who use injections. We then proceed to an asymptotic analysis (large initial population) and show that the Markov process is close to the solution of a non linear autonomous differential system. We prove both a law of large numbers and functional central limit theorem to precise the speed of convergen...
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Background: The use of mathematic modeling to better understand the spread of Hepatitis C and the impact of interventions can be invaluable for localities, states and countries with a large burden of injection drug use. New York State (NYS) is estimated to be home to a large number of people who inject drugs (PWID), however the burden of hepatitis C among this population and the impact of inter...
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PURPOSE Recent clinical trials have evaluated treatment strategies for chronic infection with hepatitis C virus (HCV) in patients co-infected with human immunodeficiency virus (HIV). Our objective was to use these data to examine the cost-effectiveness of treating HCV in an urban cohort of co-infected patients. METHODS A computer-based model, together with available published data, was used t...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2016
ISSN: 1098-3015
DOI: 10.1016/j.jval.2016.08.468